Explain why this research is important, including background knowledge

In recent years, various acute Febrile Illnesses (AFI) have emerged, and some are life-threatening. The clinical management of AFI heavily relies on accurate detection of the pathogen, which possibly could be bacteria, virus, fungi or parasites. Upon the outbreak of AFI, it is important for the clinicians to immediately know the causative pathogen so that they could decide and guide proper medications accordingly without delay. Traditional detection systems may take several days to weeks to get a definite conclusion of what the pathogens are. However, genomics or proteomics based assays could tremendously increase the sensitivity, specificity and efficiency of the detection process. Please use Genomic and Proteomic engineering knowledge to propose a strategy to conquer this clinical challenge. You could focus on the detection of the pathogen or the host response.

Please use the following format to prepare your project:

1. Significance; select an AFI for your topic and explain why this research is important, including background knowledge.

2. Specific aims, explain what goals you are attempting to achieve.

3. Research design, explain how you are going to do it.
The following 3 sections must be included in the research design.

•Materials and methods, including working flowchart and description of the technology you propose to use;

•Expected results, data interpretation and Plan B (optional) if you are not confident if this is going to work.

•Future plan, including your ideas of how this could be further developed for clinical use.
4. Literature cited