Explain the importance of systematic review and meta-analysis in evidence-based practice. What are the limitations of the systematic reviews? How can one overcome the challenges? Offer an example of a situation when a systematic review and/or meta-analysis was one of the defining points in the decision-making process, and when without it the decision might have been incorrect.

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Explain the importance of systematic review and meta-analysis in evidence-based practice. What are the limitations of the systematic reviews? How can one overcome the challenges?

Offer an example of a situation when a systematic review and/or meta-analysis was one of the defining points in the decision-making process, and when without it the decision might have been incorrect.