Description of current HIV global distribution and occurrence analysing UNAIDS, GBD and WHO’s data to highlight HIV is still an emerging disease especially in Europe and North America. Historical contextualisation of CRISPR/Cas system as editing tool against HIV-1.
Description of how current knowledge of the virus genetics enabled application of CRISPR/Cas9 nuclease to HIV-1, what is its current development against HIV-1 and its importance.
Presentation of detailed analysis of CRISPR/Cas9 gene editing targets based on studies related to the molecular mechanism of HIV-1 infection .
Description of limitations and or benefits of using CRISPR/Cas9 as a gene-editing therapy for HIv-1. Where to go next from it?.
