Determine the incidence of CHT in NI from 1981 to 2020 and to describe the incidence changes during the study period and over 10yrs block and find out if there is any statictical difference of the periods. For example; “there was a steady increase in incidence of CHT over time with an incidence of 26 cases/100,000 livebirths in 1981 vs 71/100,000 in 2019 (P < 0.00001). Results are similar to recent Republic of Ireland data (65/100,000). In ten year blocks the average incidence rose from 28 to 42, 65 and 73/100,000 live births (1980s, 1990s, 2000s and 2010s respectively)” Please support this with line charts.
Please analyze and describe between genders and any statistical differences (P value)
Please analyze and describe the birth weight (mean/median) and any correlation with increased incidence of congenital hypothyroidism of the whole periods and over 10years block periods.
Analyze and describe the mode of delivery and any correlation with increased incidence of congenital hypothyroidism of the whole periods and over 10years block periods.
Please analyze and describe gestational age and find out if there is any correction between the increased gestational age and incidence of congenital hypothyroidism
Please analyze and describe maternal age and find out if there is any correction between the increased gestational age and incidence of congenital hypothyroidism.
Please find out the mean/median of age confirmed diagnosis of hypothyroidism
Please analyze and describe the scans were done (nuclear medicine uptake scan=NM vs Ultrasound scan)
Please analyze and describe the underlying etiology
Please analyze and describe the initial dose: The average initial dose?
Please analyzes and describe the incidence of permanent vs transit hypothyroidism and any P-Value.
Please describe the presence of goiter on examination
Please analyze and describe family history and P-value.
Please describe and analyze the associated extra thyroid conditions. What was the commonest conditions in percentage and any correlation with increased incidence of congenital hypothyroidism?
Please find out the infant death rate over the whole periods and over 10yrs block.
Many thanks
