(a) What factors contribute to the proteome diversity?
(b) Write the name and one sentence description of five main posttranslational events in the cellular system.
(c) Do you think the types and complexity of glycosylation varies from cell to cell? Why?
(d) Which analytical instrument is more effective in analyzing glycan structure?
Find the paper entitled, ‘Structural basis for diverse N-glycan recognition by HIV neutralizing V1–V2–directed antibody PG16‘. (a) What critical PG16 residues are involved in glycan binding? (b) Why N-glycan is important in HIV pathogenesis? (c) Look at the glycan structure below and write the name of the type of this glycan (N-glycan or O-glycan) and Why?
