Examine the historical context of botulinum toxin which may include; 1) history of bacterium Botulinum toxin 2) the discovery of BoNTA for therapeutic use 3)the discovery of BoNTA for aesthetic purposes. Your response should also include the historical content of dermal fillers which may include;
1) the historical use of dermal fillers first used for therapeutic indications
2)the use of dermal fillers agents for Hiv-associated facial lipoatrophy
3) the historical context and development of permanent and biodegradable dermal filler agents.
