The refer/defer assessment for this module is based on the case studies that you studied on your module running in the Semester in which you were enrolled. You will submit a 3000-word report consisting of two parts, vSP4 Part 1 Histopathology Case Study Report and vSP4 Part 2 Haematopathology Case Study Report. Both parts are equally weighted.
Please refer to the relevant supporting information and recordings that are in Westminster Slidebox, and the Learning Resources, Assessment, and Panopto (or Collaborate) tabs in Blackboard.
vSP4 Part 1 (50% of the Coursework Marks)
Study the WSIs of the HE-stained sections. Using accurately labelled images to support your work, describe the histopathology of the primary tumour and the liver core biopsy. You should support your description with no more than 4 images. The figure legends will count towards the word limit. (25%, 375 words*)
Using your case as an example, discuss the histopathological investigation of the sentinel lymph node. (25%, 375 words*)
With reference to all of the evidence available to you, provide an illustrated description of the patterns of immunohistochemical staining visible with the different antibodies and discuss how these results will inform the pathologist’s report. You should support your description with no more than 8 images. The figure legends will count towards the word limit. (50%, 750 words*)
vSP4 Part 2 (50% of the Coursework Marks)
Using examples, evaluate how genetic alterations contribute to the development of the haematological malignancy presented in your case. (20%, 300 words*)
Explain why morphological examination was necessary to investigate the patient and compare the value of this technique with ONE other diagnostic method performed in your case study. (40%, 600 words*)
Discuss how targeted drugs provide new opportunities for the treatment of haematological malignancies. You should provide one example relevant to your case and briefly describe how response to treatment may be monitored. (40%, 600 words*)
